Endocrine Abstracts

Objectives: The use of thyroid hormones (TH) to treat obesity is not supported by evidence based on efficacy and safety, and this is reflected in recommendations of major international guidelines on hypothyroidism and obesity. We aimed to explore views about this practice among European thyroid specialists and their associations with respondent characteristics.Methods: Thyroid specialists from 28 countries were invited to participate in a questionnaire s...

Background: Levothyroxine (LT4) is considered the standard of care for hypothyroidism, however 5-10% of hypothyroid individuals complain of persistent symptoms despite achieving biochemical euthyroidism on LT4.Methods: 17,247 thyroid specialists from 28 countries were invited to participate in a survey. It enquired about respondents’ perceptions of the cause of hypothyroid-like persistent symptoms and how the prevalence of such complaints had change...

Background: Levothyroxine (LT4) monotherapy is the mainstay of treatment of hypothyroidism, but a sizeable minority of endocrinologists also use T3-containing treatments in some patients notwithstanding concern about their safety.Methods: 17,247 thyroidologists from 28 countries were invited to participate in a questionnaire survey. Geographic regions were defined according to the UN Statistics Division. Gross national income (GNI) information stems from...

Introduction: Pseudo Cushing syndrome (PCS) is caused by non-neoplastic over activity of the hypothalamic-pituitary-adrenal axis. Differentiating between PCS and Cushing disease (CD) can be challenging because of their overlapping clinical and biochemical features.Case presentation: 15 year old male presenting with watery diarrhea of 2 months duration occurring 3 times per day with lower limb weakness No rectal bleeding, fever, or weight loss<p class...

Introduction: Thyroid storm is a rare complication of hyperthyroidism. In pregnant patients can cause spontaneous abortions, fetal demise. Aggressive treatment is needed.Case report: 26 years female 20 weeks pregnant; Graves’ disease for five years, was on carbimazole but she discontinued since she became pregnant Shortly after that, she started to complain with progressive dyspnea at less than ordinary effort, bilateral lower limb swelling, increas...

Background: Hypothyroidism due to autoimmune thyroiditis leads to atherogenic lipid profile and metabolic changes. The formation of advanced glycation end products (AGEs) increases with hyperglycemia, hyperlipidemia and oxidative stress. Degradation of AGEs after AGEs-receptor 1-mediated intracellular uptake and renal clearance of soluble AGEs generated by certain cells like macrophages play a crucial role in the decrement of circulating AGEs level. Chemerin is an adipokine pr...

Objectives: We present findings from the UK arm of the THESIS collaboration, a pan-European survey of endocrinologists’ opinions and current practice in the management of hypothyroid and euthyroid disorders.Methods: UK clinical members of the Society of Endocrinology and the British Thyroid Association were invited to participate in an online survey.Results: 272 of 1295 (21%) eligible members completed the survey. More than 50...

Background: Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, and adipose tissues. Enhanced FGF21 production in diabetes and obesity reduces the level of LDL-C and triglycerides by suppression of hepatic SREBP-2. Hypothyroidism has also been shown to have unfavorable effects on atherogenesis and dyslipidemia. To date, the association of lipid p...

Background: Extracellular vesicles (exosomes, microvesicles) shed from tumor cells containing microRNAs can be exploited as markers of malignancy. The preoperative diagnosis of adrenocortical malignancy is difficult and microRNAs have proved useful in the diagnosis of many tumors, including adrenocortical cancer (ACC), but there have no studies to date on extracellular vesicle associated microRNAs in ACC.Aim: To evaluate the diagnostic potential of extra...

Cold nodules are one of the most common findings on scintigraphic examinations of the thyroid gland. About 5–10% of these nodules turn out to be histologically malignant. Our aim was to examine some somatogenetic alterations associated with thyroid cancer in FNA samples of the thyroid. These alterations included single nucleotide mutations (BRAF, HRAS, NRAS, KRAS) and genetic translocations (RET/PTC1, RET/PTC3, PAX8ex7/PPARgamma, PAX8ex9/PPARgamma). The SNPs were tested b...